abstract：:Earlier studies on platelet serotonin uptake in schizophrenia have given equivocal results. In this study, platelet serotonin uptake in diluted plasma was assessed in 23 drug-free and 19 neuroleptic-treated schizophrenics, compared to 70 controls. The maximal uptake rate, Vmax, was slightly but significantly lower in ...

journal_title：Biological psychiatry

authors： Lingjaerde O

更新日期：1983-12-01 00:00:00

abstract：:Sleep and 24-hr body core temperature were measured during a 2- to 3-week study interval in 15 endogenous depressives, 12 patients after remission, and 10 normal control subjects. The total sample was subdivided into one group of persons who displayed at least one sleep onset REM episode (SOREM; latency less than or e...

journal_title：Biological psychiatry

authors： Schulz H,Lund R

更新日期：1983-12-01 00:00:00

abstract：:Probenecid is used to block the transport of acid monoamine metabolites from cerebrospinal fluid (CSF), on the assumption that the resultant rise in CSF concentrations of the metabolites will reflect presynaptic "turnover" of the parent monoamine. However, CSF levels of probenecid correlate with CSF levels of the meta...

journal_title：Biological psychiatry

authors： Cowdry RW,Ebert MH,van Kammen DP,Post RM,Goodwin FK

更新日期：1983-11-01 00:00:00

abstract：:Smooth pursuit eye movements (SPEM) for two stimulus velocities (sinusoidal and triangular) were studied by visual inspection in 12 unmedicated RDC-diagnosed schizophrenic patients and in 13 matched controls. SPEM was worse in the patient group and their performance deteriorated with repeated presentations of the task...

journal_title：Biological psychiatry

authors： Bartfai A,Levander SE,Sedvall G

更新日期：1983-09-01 00:00:00

abstract：:A "risk factor" approach to affective illness is outlined. Characteristics which are correlated with vulnerability to depression (or mania) should be sought and attempts made to either modify them or elucidate a pathophysiologic link between the characteristic and the illness. Genetic factors, biochemical factors, lif...

journal_title：Biological psychiatry

authors： Nurnberger JI Jr,Jimerson DC,Bunney WE Jr

更新日期：1983-08-01 00:00:00

abstract：:Schizophrenic patients have been observed to have a significantly diminished P300 component of the event-related potential (ERP). We investigated whether this result would be obtained with high-incentive stimuli. We presented 14 unmedicated patients and 14 controls with two easily identified visual stimuli under three...

journal_title：Biological psychiatry

authors： Brecher M,Begleiter H

更新日期：1983-06-01 00:00:00

abstract：:The ability of beta-adrenergic receptors to adapt to reductions in stimulation might be impaired in depressed or schizophrenic patients. To test this hypothesis 12 normal controls, 12 depressed patients resistant to tricyclic antidepressants, and 8 chronic schizophrenic patients were treated with propranolol 160 mg/da...

journal_title：Biological psychiatry

authors： Zohar J,Bannet J,Drummer D,Fisch R,Epstein RP,Belmaker RH

更新日期：1983-05-01 00:00:00

abstract：:It is unknown whether the dexamethasone suppression test (DST) can be used to help identify patients with major depressive disorder if they have recently been abusing alcohol. We evaluated 38 male alcoholics with Research Diagnostic Criteria (RDC), the Beck Depression Inventory (BDI), and the standardized overnight 1-...

journal_title：Biological psychiatry

authors： Kroll P,Palmer C,Greden JF

更新日期：1983-04-01 00:00:00

abstract：:Bilateral electrodermal activity (EDA) was examined in depressed patients in remission. In Study 1, 26 unipolar and 24 bipolar patients were compared to 46 psychiatrically healthy controls. Subjects were exposed to 17 86-dB pure tones while skin conductance was recorded from both hands. In Study 2, which was conducted...

journal_title：Biological psychiatry

authors： Iacono WG,Tuason VB

更新日期：1983-03-01 00:00:00

abstract：:Long-term normal-dose benzodiazepine treatment in seven patients was associated with reduced urinary excretion of MOPEG (4-hydroxy-3-methoxy-phenylglycol). Following the discontinuation of the drugs a characteristic withdrawal reaction occurred, with an increase towards normal values of the MOPEG excretion levels and ...

journal_title：Biological psychiatry

authors： Petursson H,Bond PA,Smith B,Lader MH

更新日期：1983-02-01 00:00:00

abstract：:Elderly depressed patients who met the research diagnostic criteria (RDC) for major depressive illness, resistant to other types of treatment, were treated with phenelzine, a nonselective monoamine oxidase (MAO) inhibitor, for a period of 2 to 7 weeks, following 2 weeks of placebo washout period. Dosage ranged from 15...

journal_title：Biological psychiatry

authors： Georgotas A,Friedman E,McCarthy M,Mann J,Krakowski M,Siegel R,Ferris S

更新日期：1983-02-01 00:00:00

abstract：:The author presents six cases of pseudodementia of varying degrees of severity that illustrate the difficulty in making purely clinical diagnoses of pseudodementia and demonstrate the usefulness of ECT in this condition in treatment-resistant patients. In addition, issues of cerebral laterality are raised by one case ...

journal_title：Biological psychiatry

authors： Allen RM

更新日期：1982-12-01 00:00:00

abstract：:Taken as a whole the data presented provide support for Klein's conceptualization of etiologically distinct subtypes of depression. A basic limbic system derangement in endogenous depression is suggested by the higher incidence of DST nonsuppression. Beck's theory that all depressions result from a primary cognitive d...

journal_title：Biological psychiatry

authors： Giles DE,Rush AJ

更新日期：1982-11-01 00:00:00

abstract：:The possibility of characterizing subgroups of depressive disorders by biological markers was studied by means of the dexamethasone suppression test (DST), the 24-hr urinary free cortisol (UFC), the growth hormone response to the insulin tolerance test (ITT), and polygraphic sleep recordings. Forty-five hospitalized p...

journal_title：Biological psychiatry

authors： Berger M,Doerr P,Lund R,Bronisch T,von Zerssen D

更新日期：1982-11-01 00:00:00

abstract：:A group of 29 bipolar manic-depressives completed a 12-month double-blind cross-over trial of low-dose and high-dose lithium prophylaxis. Twelve patients relapsed, and significantly more of the relapses occurred during the low-dose 6-month phase of the trial. There was a trend for relapse to occur within 2 months of a...

journal_title：Biological psychiatry

authors： Waters B,Lapierre Y,Gagnon A,Cahudhry R,Tremblay A,Sarantidis D,Gray R

更新日期：1982-11-01 00:00:00

abstract：:Platelet MAO activity in schizophrenics was significantly decreased, by about 15%, after 3 weeks of treatment with haloperidol. Treatment with thioridazine or butaperazine also tended to decrease platelet MAO activity. The neuroleptic-induced decrease began to appear within a few days of treatment and did not show tol...

journal_title：Biological psychiatry

authors： Ho BT,Smith RC,Kralik P,Allen R,Schoolar J,Khan M,DeJohn C

更新日期：1982-08-01 00:00:00

abstract：:To confirm and extend previous observations concerning the correlation between cell-mediated immunity and psychiatric diseases, 511 patients with schizophrenia, cerebral atrophy, dementia, and mental retardation, and 32 control subjects and 27 control patients were skin-tested with human brain S-100 protein and human ...

journal_title：Biological psychiatry

authors： Janković BD,Jakulić S,Horvat J

更新日期：1982-06-01 00:00:00

abstract：:The effect of nortriptyline was assessed on the EEG sleep of 20 inpatients with major depressive syndrome. While 25 mg of nortriptyline had an immediate effect on REM sleep variables, relatively little influence on sleep continuity measures was noted. Subsequent administration of 75 and 100 mg of nortriptyline produce...

journal_title：Biological psychiatry

authors： Kupfer DJ,Spiker DG,Rossi A,Coble PA,Shaw D,Ulrich R

更新日期：1982-05-01 00:00:00

abstract：:The dexamethasone suppression test (DST) and sleep EEG were compared in three different descriptive diagnostic schemes in 70 adult patients with nonpsychotic, unipolar major depressive disorder according to Research Diagnostic Criteria. Endogenous (E)/nonendogenous (NE), primary/secondary, and Winokur's family history...

journal_title：Biological psychiatry

authors： Rush AJ,Giles DE,Roffwarg HP,Parker CR

更新日期：1982-03-01 00:00:00

abstract：:Primary depressive illness comprises a wide variety of clinical presentations which may represent disorders with different underlying biology, life course, and treatment response. In order to explore possible correlates of such clinical heterogeneity, we have constructed a rating scale for atypical depressive illness....

journal_title：Biological psychiatry

authors： Silberman EK,Post RM

更新日期：1982-03-01 00:00:00

abstract：:A group of 231 psychiatric patients were evaluated (with the Wechsler Adult Intelligence Scale and the Halstead-Reitan Neuropsychological Test Battery) before and after electroconvulsive therapy. Improvement during the course of therapy was shown in 96% of the measures and significant improvement (p less than 0.05) oc...

journal_title：Biological psychiatry

authors： Malloy FW,Small IF,Miller MJ,Milstein V,Stout JR

更新日期：1982-01-01 00:00:00

abstract：:The benzodiazepines are generally safe and effective drugs with usually only minor side effects, dose-related sedation being the most common. A range of paradoxical effects can occur of which release of aggressive and hostile feelings has excited most attention. These responses are idiosyncratic however, as most patie...

journal_title：Biological psychiatry

authors： Lader MH,Petursson H

更新日期：1981-12-01 00:00:00

abstract：:Previous studies of the haloperidol-induced increase in dopamine (DA) receptor number have not emphasized the existence of individual differences. The present study evaluated DA receptor number in individual rat and mouse caudates after haloperidol or drug-free feeding. After 3 months of haloperidol treatment of rats ...

journal_title：Biological psychiatry

authors： Bannet J,Belmaker RH,Ebstein RP

更新日期：1981-11-01 00:00:00

abstract：:Certain investigators have asserted that the illness of anorexia nervosa is a form of hypothalamic disturbance. The relationship between 24-hr urine 3-methoxy-4-hydroxyphenylglycol (MHPG) and dexamethasone suppression tests was examined in 13 female patients with AN diagnosed by RDC. Patients showed a consistent assoc...

journal_title：Biological psychiatry

authors： Gwirtsman HE,Gerner RH

更新日期：1981-10-01 00:00:00

abstract：:Abnormal adrenocortical regulation has been reported in patients with endogenous depression, including excessive cortisol production with loss of circadian periodicity and decreased suppression by dexamethasone. The inhibitory effect of the neurotransmitter norepinephrine (NE) on the hypothalamic-pituitary adrenal (HP...

journal_title：Biological psychiatry

authors： Sotsky SM,Lake CR,Goodwin FK

更新日期：1981-07-01 00:00:00

abstract：:In crossover design with alternate assignment to order, 18 hyperkinetic children were treated with eyes-open rotational vestibular stimulation and with control contact, each eight times over 4-week periods. On behavioral ratings by teachers, they scored better after eight sessions of rotational stimulation than after ...

journal_title：Biological psychiatry

authors： Bhatara V,Clark DL,Arnold LE,Gunsett R,Smeltzer DJ

更新日期：1981-03-01 00:00:00

abstract：:The specific binding of (3H)kainic acid (KA) to high- and low-affinity receptor sites was assayed in postmortem samples from the brains of patients affected with Huntington's disease (HD) and age-matched controls. Treatment of rat brain with conditions that closely mimic the temperature gradient occurring in postmorte...

journal_title：Biological psychiatry

authors： London ED,Yamamura HI,Bird ED,Coyle JT

更新日期：1981-02-01 00:00:00

abstract：:Dietary administration of L-tryptophan to rats failed to increase blood platelets. Instead platelet counts were decreased after feeding either a tryptophan-deficient or tryptophan-enriched (10%) diet, but were unchanged in animals on a 1% tryptophan diet. Platelet median volumes were not affected by any of these dieta...

journal_title：Biological psychiatry

authors： Sakuma M

更新日期：1980-12-01 00:00:00

abstract：:Recall of dichotically presented digit strings was compared between normal controls and 18 chronic schizophrenic patients tested over 12 weeks on chlorpromazine, placebo, and chlorpromazine reinstatement. Patients were subgrouped according to (i) arousal as indexed by orienting responses in a tone-habituation sequence...

journal_title：Biological psychiatry

authors： Gruzelier JH,Hammond NV

更新日期：1980-10-01 00:00:00

abstract：:Lithium-treated and drug-free individuals were each given 0.5 mg epinephrine subcutaneously and blood samples withdrawn for measurement of plasma cyclic AMP and cyclic GMP. The rise in plasma cyclic GMP in response to epinephrine was found to be partially inhibited by lithium treatment, and previous reports of lithium...

journal_title：Biological psychiatry

authors： Belmaker RH,Kon M,Ebstein RP,Dasberg H

更新日期：1980-02-01 00:00:00

abstract：:Reduced platelet MAO activity has been previously reported as a biochemical marker for a subgroup of psychiatric patients, including some chronic schizophrenics. As tryptamine metabolism appears to be sensitive to alterations in MAO activity, urinary tryptamine excretion was measured in chronic schizophrenics with low...

journal_title：Biological psychiatry

authors： Sullivan JL,Coffey CE,Basuk B,Cavenar JO,Maltbie AA,Zung WW

更新日期：1980-02-01 00:00:00

abstract：:Male hooded rats were observed for 6 days following implantation with slow-release subcutaneous pellets containing LSD, mescaline, or control vehicle solution. In animals housed in isolation cages, continuous hallucinogen administration resulted in a gradual increase in head twitches and catatonic postures which peake...

journal_title：Biological psychiatry

authors： Ellison G,Ring M,Ross D,Axelrood B

更新日期：1980-02-01 00:00:00

abstract：:The effects of two putative attention-engaging maneuvers on tracking performance were studied in three groups of subjects: inpatients (n = 19), outpatients (n = 19), and controls (n = 20). One method involved realerting subjects during tracking by repeating instructions to track carefully. The second method, a signal ...

journal_title：Biological psychiatry

authors： Pivik RT

更新日期：1979-12-01 00:00:00

abstract：:A high incidence of behavioral and learning difficulties has been found in juvenile seizure-prone baboons presented with a graded series of operant behavioral task challenges. The animals fell into two distinct groups based upon the rate at which their operant performance was able to develop, the amount of day-to-day ...

journal_title：Biological psychiatry

authors： Weinberger SB,Killam EK

更新日期：1979-06-01 00:00:00

abstract：:Tricyclic antidepressants are thought to act primarily via effects on adrenergic neurotransmitters. Recent research supports the concept that a major function of the central adrenergic system is the modulation of cerebral fluid dynamics. Based on this concept, studies in the rat were conducted to assess the effects of...

journal_title：Biological psychiatry

authors： Preskorn SH,Hartman BK

更新日期：1979-04-01 00:00:00

abstract：:Evidence is presented for the occurrence of a locus for schizotaxia on the short arm of chromosome 6. This derives from study of 63 informative members of seven pedigrees in which the proband and a parent (or a sib of parent) suffered with schizophrenia and other kin were either normal or fell within a spectrum of con...

journal_title：Biological psychiatry

authors： Turner WJ

更新日期：1979-02-01 00:00:00

abstract：:EEGs were recorded for two groups of chronic alcoholics who scored at opposite extremes on the Shipley Institute of Living Scale. The groups were matched in terms of age and drinking history variables and were compared to age-matched control subjects for left and right precentral (F-T) and postcentral (C-O) placements...

journal_title：Biological psychiatry

authors： Coger RW,Dymond AM,Serafetinides EA,Lowenstam I,Pearson D

更新日期：1978-12-01 00:00:00

abstract：:To examine the nature of impaired smooth pursuit eye movement (SPEM) in schizophrenia, 16 hospitalized schizophrenics in the acute phase and 16 hospitalized nonpsychotic patients were studied. The experiment consisted of five 30-sec visual tracking phases: (i) base line (no distraction); (ii) auditory-visual distracti...

journal_title：Biological psychiatry

authors： Pass HL,Salzman LF,Klorman R,Kaskey GB,Klein RH

更新日期：1978-10-01 00:00:00

abstract：:Testosterone pretreatment (1.0-4.0 mg/kg) attenuated, in a dose-response fashion, the induction of stereotyped behavior and hyperactivity by pargyline (0.25, 4.0 mg/kg) and beta-phenylethylamine (8.0, 16.0 mg/kg) in preubertal, male rats. The dyskinetic movements induced by pargyline and beta-phenylethylamine were pro...

journal_title：Biological psychiatry

authors： Freemark M,Stoff DM,Moja EA,Gillin JC,Wyatt RJ

更新日期：1978-08-01 00:00:00

abstract：:The effect of Vincamine and Piracetam, two geriatric drugs, on sleep behavior of the laboratory cat was studied. The animals were chronically prepared for recording of the EEG of the cerebral cortex, the lateral geniculate body, and the hippocampus, and for recording of eye movements, the muscular tonus and respiratio...

journal_title：Biological psychiatry

authors： Glatt A,Klebs K,Koella WP

更新日期：1978-08-01 00:00:00